3-Chloro-4-(methoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride)

Name	[3-chloro-4-(methoxycarbonyl)phenyl]boronic acid
Synonyms	AKOS BRN-0545 METHYL 4-BORONO-2-CHLOROBENZOATE 3-Chloro-4-(methoxycarbonyl)phenylboronic acid 3-CHLORO-4-(METHOXYCARBONYL)PHENYLBORONIC ACID (3-Chloro-4-(methoxycarbonyl)phenyl)boronicacid (3-CHLORO-4-METHOXYCARBONYL)BENZENEBORONIC ACID [3-chloro-4-(methoxycarbonyl)phenyl]boronic acid (4-(Methoxycarbonyl)-3-chlorophenyl)boronic acid 3-Chloro-4-(methoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride)
CAS	603122-82-3
EINECS	600-419-4
InChI	InChI=1/C8H8BClO4/c1-14-8(11)6-3-2-5(9(12)13)4-7(6)10/h2-4,12-13H,1H3

Hazard Symbols	Xi - Irritant
Hazard Note	Irritant

Introduction	3-chloro-4-methyl formate phenylboronic acid is an organic intermediate, which can be made of 2-chloro-4-bromobenzoic acid Methyl ester reacts with pinacol biborate to prepare pinacol 3-chloro-4-methoxycarbonylphenylborate, and then oxidize it with sodium periodate. Methyl 3-chloro-4-formate phenylboronic acid can be used for Suzuki coupling reactions.
appearance	white powder
Application	3-chloro-4-methyl formate phenylboronic acid is a white powder, used as an organic intermediate, OLED intermediate.
preparation	adding pinacol borate (8.6g,31.4 mmol),PdCl2(PPh3)2(0.42mmol) and KOAc(94.2mmol) to dioxane (154 mL) solution of methyl 2-chloro-4-bromobenzoate (31.4 mmol), stirring the mixture at 100 ℃ under nitrogen for 2-6 hours. Dilute the mixture with EtOAc and water. The organic layers were separated, washed with brine, dried by MgSO4, and evaporated. The residue was purified by silica gel column chromatography (hexane/EtOAc 5/1) to give 3-chloro-4-methoxycarbonylphenylboronic acid pinacol ester. NH4OAc(66.2mmol) and NaIO4(14.2g,66.4mmol) were added to the suspension of the above product (29.4mmol) in acetone (175mL) and water (175mL), and the mixture was stirred at room temperature for 15 hours. The solvent was evaporated and the residue was diluted with EtOAc. The organic layer was separated, washed with water and salt water, dried by MgSO4, and evaporated under reduced pressure to obtain the title compound, which is a white solid.
store	store at room temperature

Last Update：2024-04-10 22:29:15

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3-Chloro-4-(methoxycarbonyl)phenylboronic Acid (contains varying amounts of Anhydride) Request for Quotation